For example, azithromycin that has been administered to treat patients with COVID-19 could cause mitochondrial toxicity, overproduction of reactive oxygen species (ROS), and DNA oxidative damage (Tyszka et al., 2020). No Time to Wait: Securing the Future from Drug-Resistant Infections. The negative impact of high-concentration release of different kinds of biocides and antibiotics in the environment and their effects on AMR enrichment and resistance dissemination are demonstrated in Figure 2. When submitting a manuscript to Frontiers in Microbiology, authors must submit the material directly to one of the specialty sections. (2019). Increase in methicillin-resistant Staphylococcus aureus acquisition rate and change in pathogen pattern associated with an outbreak of severe acute respiratory syndrome. For instance, teicoplanin, a narrow-spectrum antibiotic that is primarily active against Gram-positive organisms such as staphylococcal infections, previously exhibited efficacy to hinder the first stage of the viral life cycle of the Middle East respiratory syndrome coronavirus (MERS-CoV) in host cells (Zhou et al., 2016). Infect. Unfortunately, off-target sites of majority of the approved antibiotics include mitochondria, which are evolutionary linked to prokaryote cells (Tyszka et al., 2020). Int. A., Ng, T. M., Habib, A. G., Singh, K., Kumarasinghe, G., and Tambyah, P. A. A., Jagadeesan, B., Goodburn, K., Grunwald, L., Jensen, O. N., Jespers, A. D., et al. At Frontiers, we publish all articles that are scientifically correct. Record Number of Countries Contribute Data Revealing Disturbing Rates of Antimicrobial Resistance. Editors’ geographical locations. ISSN: 2235-2988. For a complete guide how to prepare your manuscript refer to the journal's instructions to authors. Frontiers in Environmental Microbiology (FEM) publishes original research papers on all aspects of environmental microbiology relevant to temperate, tropical and subtropical regions. Microbiol. 2019-20 Frontiers in Microbiology 影響指數是 4.190。 75%的科學家預測 Frontiers in Microbiology 2020-21影響指數將在此 4.5 ~ 5.0 範圍內。 Frontiers in Microbiology的最新影響指數分區 為Q1。 71:15. doi: 10.1093/cid/ciaa243. Generally, biocides are antimicrobial compounds present in household disinfectants, sanitizers, and cleaners, whose inappropriate usage might consequently result in the occurrence of AMR (Levy, 2002; Pal et al., 2015; Webber et al., 2015). CiteScore 2.5 . Infect. This work was supported by Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Immune response in severe infection: could life-saving drugs be potentially harmful? 148:e199. 1245 73 12.68. Unfortunately, recent studies reveal that, in several countries, common and extensive use of antibiotic treatment for COVID-19 hospitalized patients is considered as a part of the routine treatment package (No Authors, 2020). The rising concerns about excessive use of antimicrobials and biocides and taking too much hygiene also need to be addressed during this pandemic due to their impacts on AMR, public health, and the environment. 395:10223. doi: 10.1016/S0140-6736(20)30183-5, Huang, Y., Yang, R., Xu, Y., and Gong, P. (2020b). However, the present data suggest that co-administration of azithromycin with hydroxychloroquine showed promising outcomes in a small proportion of COVID-19 patients and could reduce or eliminate the viral load (Gautret et al., 2020). 80:6. doi: 10.1016/j.jinf.2020.03.019, Wang, Z., Yang, B., Li, Q., Wen, L., and Zhang, R. (2020b). 5.206. support@frontiersin.org. 55:105924. doi: 10.1016/j.ijantimicag.2020.105924, Lansbury, L., Lim, B., Baskaran, V., and Shen, L. W. (2020). 3.633. J. Antimicrob. Frontiers in Computational Neuroscience. (2020). Dis. 3.900. Mitochondria are membrane-bound organelles present in almost all eukaryotic cells and responsible for orchestrating cellular energy production and acting as signaling hubs in antibacterial and antiviral immune responses (Osellame et al., 2012). Coronavirus Disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up. Frontiers journals rank among the world’s most-cited in their fields — including top most-cited in neurosciences, microbiology, plant science and psychology.. It is noteworthy to be highlighted that the inappropriate use of antibiotics could considerably and silently lead to AMR development during this global outbreak (Murray, 2020). It is noteworthy to indicate that COVID-19 cases that have been administered empiric use of antibiotics may also front onto subsequent complications due to co-infection by antimicrobial-resistant bacterial agents (Rawson et al., 2020). 5:1. doi: 10.4161/viru.26907, Stoker, M. L., Newport, E., Hulit, J. C., West, A. P., and Morten, K. J. Agents. Therefore, incorporation of strategic algorithms for accurate diagnosis and effective treatment of invasive fungal disease is vital in critically ill patients with COVID-19 and subsequently may result in a definitive diagnosis and successful antifungal therapy throughout the period of severe respiratory distress. Infect. doi: 10.1016/j.jgar.2020.02.021, Maillard, J. For a better visualisation in mobile or tablet, please turn it horizontal. Frontiers in Microbiology IF is decreased by a factor of 0.08 and approximate percentage change is -1.87% when compared to preceding year 2017, which shows a falling trend. Int. (2003). Furthermore, mitochondria are among the most important intracellular organelles vulnerable to the effects of antibiotic treatment (Tyszka et al., 2020). (2020). 56:1. doi: 10.1016/j.ijantimicag.2020.105949, Gilbert, P., and McBain, A. J. Agents. Journal Impact 2018 di Frontiers in Microbiology è 4.190 (Ultimi dati nel 2019). Journals range from life sciences and health to engineering, robotics and humanities. (2018). Impact Factor 3.644. Recently, it was proposed that this antibiotic can be potentially recommended as a promising treatment option for patients with SARS-CoV-2 (formerly 2019-nCoV) (Baron et al., 2020). Im Vergleich zu historischen Journal Impact sank der Journal Impact 2019 von Frontiers in Microbiology um 1.87 %. (2020). 70:8. doi: 10.1093/jac/dkv109. “Investigation of silver biocide as a disinfection technology for spacecraft-an early literature review,” in Proceedings of the 48th International Conference on Environmental Systems ICES-2018-82, Albuquerque, NM. Baron, S. A., Devaux, C., Colson, P., Raoult, D., and Rolain, J. M. (2020). South America . However, these practices significantly differ around various clinical settings worldwide. doi: 10.1111/myc.13096, Lai, C. C., Shih, T. P., Ko, W. C., Tang, H. J., and Hsueh, P. R. (2020). According to Randall et al. Chemical Engineering. In these patients and in particular upon hospitalization, the situation could be progressively deteriorated due to nosocomial infections by multidrug-resistant (MDR) microorganisms. doi: 10.20944/preprints202004.0269.v1, Wang, L., He, W., Yu, X., Hu, D., Bao, M., Liu, H., et al. Unfortunately, it is also predicted that AMR-associated deaths can reach up to 10 million deaths per year by 2050, if the world could not tackle the COVID-19 crisis (O’Neill, 2014). Frontiers in Microbiology is a member of the Committee on Publication Ethics. Frontiers in Cell and Developmental Biology. (O’Neill). Characteristics of COVID-19 patients dying in Italy. Antimicrobial use, drug-resistant infections and COVID-19. DelPaso Films, Casa productora en Puerto vallarta que brinda servicio profesional de Video Producción, video aéreo con drones en Puerto Vallarta y renta de equipo. Possible implications of biocide accumulation in the environment on the prevalence of bacterial antibiotic resistance. Potential impact of increased use of biocides in consumer products on prevalence of antibiotic resistance. Note that 2019 Journal Impact are reported in 2020; they cannot be calculated until all of the 2019 publications have been processed by the indexing agency. J. Ind. Available online at: https://wellcomecollection.org/works/rdpck35v, Osellame, L. D., Blacker, T. S., and Duchen, M. R. (2012). 7:398. doi: 10.3389/fmed.2020.00398, Ruan, Z., and Feng, Y. World J. Asia. While the world is working hard to overcome and control the coronavirus disease 2019 (COVID-19) pandemic, it is also crucial to be prepared for the great impacts of this outbreak on the development of antimicrobial resistance (AMR). On the other hand, it is also presumed that if the biocide concentrations reach the sub-minimum inhibitory concentration (sub-MIC), this event may augment the selective pressure, boost the horizontal gene transfer (HGT), and drive the evolution of AMR (McBain et al., 2002; Gilbert and McBain, 2003). Eur. Dis. It was estimated from separate studies that approximately 1 to 10% of the patients with COVID-19 contracted secondary bacterial co-infections (Lai et al., 2020). 5:779. doi: 10.1038/s41564-020-0739-4, O’Neill, J. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Frontiers Editorial Office Avenue du Tribunal Fédéral 34 CH – 1005 Lausanne Switzerland Tel +41(0)21 510 17 40 Fax +41 (0)21 510 17 01, microbiology.editorial.office@frontiersin.org, Frontiers Support Tel +41(0)21 510 17 10 Fax +41 (0)21 510 17 01 support@frontiersin.org, Avenue du Tribunal Fédéral 34 CH – 1005 Lausanne Switzerland, Tel +41(0)21 510 17 40 Fax +41 (0)21 510 17 01, For all queries regarding manuscripts in Review and potential conflicts of interest, please contact J. Biol. Resist. Authors. As we are taking much better account of the unseen majority of life, unravel the biogeochemical processes that microbes facilitate, thereby making planet Earth habitable for all forms of life; as we increasingly identify the rules by which microorganisms interact with co-evolving viruses and macroorganisms in health and disease; and as we find more and better strategies to mitigate the detrimental effects of anthropogenic activities on the abundance, diversity, distribution and activity of microbial communities, Frontiers in Microbiology will be the 21st century approach to communicate all this progress to both the specialist and a wider audience of readers in the field. Biochem. Frontiers in Behavioral Neuroscience. Infect. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. 16:964. doi: 10.1186/s12864-015-2153-5, Partridge, S. R., Kwong, S. M., Firth, N., and Jensen, S. O. Frontiers in Microbiology is the world’s most-cited Microbiology journal & ranks in the top Impact Factor and CiteScore percentiles. How patients with chronic liver diseases succeed to deal with COVID-19? Before the emergence of the SARS-CoV-2 pandemic, the world was already demanding immediate, coordinated, and ambitious actions to avert the potentially disastrous AMR crisis and its related economic and health consequences. Frontiers in Cellular and Infection Microbiology. The antimicrobial activity of most of these products is basically due to the presence of biocide materials in their formulations. Im Vergleich zu historischen Journal Impact sank der Journal Impact 2019 von Frontiers in Microbiology um 1.87 %. (2020). The World Health Organization (WHO) is worried that the trend will later be fueled by the wrong consumption of antibiotics during the COVID-19 pandemic. Available online at: https://www.cebm.net/covid-19/what-is-the-evidence-for-use-of-macrolide-antobiotics-for-treatmetnof-covid-19 (accessed April 28, 2020). Metab. Chemistry. Africa . The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Clin. Heard, K. L., Hughes, S., Mughal, N., and Moorea, L. S. P. (2020). Lancet Microbe. This defies the long-held belief that publishing high volumes reduces quality. Frontiers in Microbiology Impact Factor, IF, number of article, detailed information and … Biocidal agents used for disinfection can enhance antibiotic resistance in gram-negative species. Bacterial Coinfections in Lung Tissue Specimens from Fatal Cases of 2009 Pandemic influenza A (H1N1)-United States, May-August 2009. (2007). Antimicrobial resistance in the age of COVID-19. (2019). Xu, X. W., Wu, X. X., Jiang, X. G., Xu, K. J., Ying, L. J., Ma, C. L., et al. J. Glob. J. Microbiol. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Within this specialty, Microbiotechnology covers a broad depth and breadth of environmental microbiology. Frontiers Media SA is a publisher of peer-reviewed open access scientific journals currently active in science, technology, and medicine.It was founded in 2007 by a group of neuroscientists, including Henry and Kamila Markram, and later expanded to other academic fields. 4 sections . doi: 10.1016/S2666-5247(20)30065-3, Hsu Freelance, J. 71:15. doi: 10.1093/cid/ciaa272, Wassenaar, T., Ussery, D., Nielsen, L., and Ingmer, H. (2015). Frontiers in. 55:105944. doi: 10.1016/j.ijantimicag.2020.105944, Braga, T., Marujo, P., Pomba, C., and Lopes, M. (2011). 2. 2019 novel coronavirus (2019-nCoV) outbreak: a new challenge. Generally, it is supposed that high concentrations of such microbicidal agents could completely kill most bacterial species especially those that provide beneficial services to the ecosystem and to other living organisms while inhibiting the emergence of drug-resistant microorganisms (Murray, 2020). Microbiology and Molecular Biology Reviews. Li, W., Calle, L. M., Hanford, A. J., Stambaugh, I., and Callahan, M. R. (2018). J. Infect. 291:17. doi: 10.1074/jbc.M116.716100, Keywords: coronavirus disease 2019 (COVID-19), antimicrobial resistance, antibiotics, biocides, disinfectants, selective pressure, mitochondria, Citation: Rezasoltani S, Yadegar A, Hatami B, Asadzadeh Aghdaei H and Zali MR (2020) Antimicrobial Resistance as a Hidden Menace Lurking Behind the COVID-19 Outbreak: The Global Impacts of Too Much Hygiene on AMR. Clin. However, there is much controversy whether antibiotics favor current treatments used for COVID-19 or may interfere with the host immune functions. Frontiers in Environmental Microbiology (FEM) publishes original research papers on all aspects of environmental microbiology relevant to temperate, tropical and subtropical regions. Lancet 395:10223. The impact factor (IF) 2018 of Frontiers in Microbiology is 4.19, which is computed in 2019 as per it's definition. Available online at: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm58e0929a1.htm (accessed September 29, 2009). With an Impact Factor of 4.076, Frontiers in Microbiology is the 3rd most cited of all journals in the category of Microbiology, with a total of 8,498 citations in 2016 to 2,085 articles published in 2014 and 2015 (Figure 1). J. Infect. Unfortunately, there were some reports on death of COVID-19 cases who experienced further bacterial co-infections like what was observed for other viral infections (Yap et al., 2004; Centers for Disease Control and Prevention, 2009; Huang et al., 2020b; Li et al., 2020; Wang et al., 2020a). Active efflux, a common mechanism for biocide and antibiotic resistance. Efflux-mediated antimicrobial resistance. L'100% degli scienziati prevede che Frontiers in cellular and infection microbiology Journal Impact 2019 sarà compreso tra 4.0 ~ 4.5. Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., et al. Although these hygiene practices may decline the dissemination of AMR that is regarded as a promising consequence, there is also a possibly threatening impact for emerging drug resistance, which can originate from elevated consumption of such antimicrobial products (Buffet-Bataillon et al., 2012; Murray, 2020). (2016). Dis. Dis. Home; Apartment; Beaches; Leisure & Visits. Front. (2020). J. Infect. Frontiers in. At Frontiers, we publish all articles that are scientifically correct. Clin. Besides, there is much environmental concern about the unusual release and dissemination of higher concentrations of biocide-based products into the surface and underground waters and also wastewater treatment systems during the SARS-CoV-2 pandemic (Buffet-Bataillon et al., 2012). The Journal Impact Quartile of Frontiers in Microbiology is Q1 . Effect of triclosan or a phenolic farm disinfectant on the selection of antibiotic-resistant Salmonella enterica. J. Antimicrob. How covid-19 is accelerating the threat of antimicrobial resistance. microbiology.editorial.office@frontiersin.org, For queries regarding Research Topics, Editorial Board applications, and journal development, please contact Compared with historical Journal Impact data, the Metric 2019 of Frontiers in cellular and infection microbiology dropped by 4.86% . |, Antimicrobials, Resistance and Chemotherapy, https://doi.org/10.3389/fmicb.2020.590683, Centers for Disease Control and Prevention, 2009, European Centre for Disease Prevention and Control, 2017, The Center for Evidence Based Medicine, 2020, https://www.cdc.gov/mmwr/preview/mmwrhtml/mm58e0929a1.htm, https://www.ecdc.europa.eu/en/publications-data/ecdc-country-visit-italy-discuss-antimicrobial-resistance-issues, https://www.who.int/antimicrobial-resistance/interagency-coordination-group/final-report/en, https://www.epicentro.iss.it/en/coronavirus/sars-cov-2-analysis-of-deaths, https://wellcomecollection.org/works/rdpck35v, https://www.cebm.net/covid-19/what-is-the-evidence-for-use-of-macrolide-antobiotics-for-treatmetnof-covid-19, https://www.who.int/news-room/detail/01-06-2020-record-number-of-countries-contribute-data-revealing-disturbing-rates-of-antimicrobial-resistance, https://www.who.int/publications-detail/covid-19-strategy-update-13-april-2020, Creative Commons Attribution License (CC BY). 16:2. doi: 10.1128/CMR.16.2.189-208.2003. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. frontiers in immunology impact factor frontiers in immunology impact factor. Frontiers in Microbiology has an Impact Factor of 4.165 and is the 2nd most-cited open-access journal in Microbiology. The importance of infection control and prevention measures such as social distancing, hand hygiene, and self-isolation has now been advised at a communal level (Rezasoltani et al., 2020). The Journal Impact Quartile of Frontiers in cellular and infection microbiology is Q1 . doi: 10.1136/bmj.m606, Yap, F. H. Y., Gomersall, C. D., Fung, K. S. C., Ho, P. L., Ho, O. M., Lam, P. K. N., et al. BacWGSTdb, a database for genotyping and source tracking bacterial pathogens. This is a short guide how to format citations and the bibliography in a manuscript for Frontiers in Microbiology. Full-Text PDF (191KB) View 225 Downloads 53. Glycopeptide antibiotics potently inhibit cathepsin l in the late endosome/lysosome and block the entry of ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). 238 21 77 3721. Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19? December 13, 2020 Uncategorized Uncategorized Although antibiotic therapy to combat bacterial pneumonia is generally accepted in clinical practice for H1N1 influenza, the condition is essentially different and unclear in SARS-CoV-2-related pneumonia. Frontier's is publishing 107 peer-reviewed open-access journals with Impact Factors on 45 journals and CiteScore on 52 journals ... Cellular and Infection Microbiology. Chai, L. Y. Centers for Disease Control and Prevention (2009). Aim and Scopes. The results of synthesis study suggest that primary production in some regions of the ocean may be an order of magnitude greater than originally predicted: Frontiers in Marine Science . Microbiology-Sgm Impact Factor, IF, number of article, detailed information and journal factor. Congratulations to our authors, reviewers and editors for pushing boundaries, accelerating new solutions, and helping all of us to live healthy lives on a healthy planet. 29:6. doi: 10.1038/sj.jim.7000324, McCarlie, S., Boucher, C. E., and Bragg, R. (2020). For instance, during the outbreaks of the former emerging pathogen severe acute respiratory syndrome (SARS) epidemic, there was evidence of an increase in the prevalence of resistant bacterial infections such as methicillin-resistant Staphylococcus aureus (MRSA) in the hospital environment (Chai et al., 2005; European Centre for Disease Prevention and Control, 2017). 5:1. doi: 10.1556/EuJMI-D-14-00038, Webber, M. A., Whitehead, R. N., Mount, M., Loman, N. J., Pallen, M. J., and Piddock, L. J. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Soc. 82:5. doi: 10.4315/0362-028X.JFP-18-373, European Centre for Disease Prevention and Control (2017). It seems that the gigantic use of disinfectants may be implemented for a prolonged time as long as the pandemic remains all over the world. On the other hand, enrichment of biocide and antibiotic concentrations at the sub-minimum inhibitory concentration (sub-MIC) in the environment may augment the selective pressure phenomenon, boost the horizontal gene transfer (HGT), and drive the evolution of antimicrobial resistance (AMR) that lead to the selection of antibiotic-resistant bacteria. Clin. Impact Factor. J. Antimicrob. COVID-19 and fungal superinfection. (2020) suggested that COVID-19 fungal research should consider invasive Candida spp. Key to success. Food Prot. Frontiers in Microbiology is composed of the following Specialty Sections: Antimicrobials, Resistance and Chemotherapy, Microbe and Virus Interactions with Plants, Microbiological Chemistry and Geomicrobiology. The main mechanisms of antibiotic resistance are alteration in membrane components leading to reduced permeability of the cell membrane, modification in cell wall proteins as the common antibiotic targets, inhibiting or limiting uptake of a drug, bypassing the pathway (compensatory tack) inhibited by a drug, degrading and inactivation of a drug by modification/degradation enzymes, and pumping out of a drug by various types of active efflux pumps. Lancet. Home; Apartment; Beaches; Leisure & Visits. Compared with historical Journal Impact data, the Metric 2019 of Frontiers in Microbiology dropped by 1.87% . Current data also suggest that some types of disinfectants can be taken via inhalation route and oral pathways and, after crossing the biological barriers, can accumulate in host tissues including lungs, liver, kidneys, stomach, brain, and blood, resulting in adverse effects on human health (Li et al., 2018). Bacterial co-infections have been regarded as an important motive of morbidity and mortality during viral infections and also have been reported to be engaged in COVID-19, although by a low proportion of COVID-19 patients (Huang et al., 2020a; Lansbury et al., 2020; Li et al., 2020). 47:6. doi: 10.1042/BST20190280, Surbatovic, M., Jevdjic, J., Veljovic, M., Popovic, N., Djordjevic, D., and Radakovic, S. (2013). In total, Frontiers articles have received more than 700,000 citations to date.. Our journals also have some of the highest citation rates. Frontiers in Microbiology . ISSN: 1350-0872. 39:5. doi: 10.1016/j.ijantimicag.2012.01.011, Cao, J., Tu, W., Cheng, W., Yu, L., Liu, Y., Hu, X., et al. BMC Genomics. The COVID-19 pandemic once again emphasizes the necessity to consider bacterial co-infections and secondary infections during and after the viral outbreaks, respectively. COVID-19 associated pulmonary aspergillosis. Elements. Sci. Ab 2008 wurde das Projekt als kommerzielles Unternehmen Frontiers Media SA weitergeführt. These antimicrobial agents can affect mitochondrial function and ATP production and also induce cell death pathways (Surbatovic et al., 2013; Singer, 2014; Zhang et al., 2020). J. 65, 60–72. 63, 528–534. Lancet. Microbiol. 3.900. Biotechnol. Frontiers is based in Lausanne, Switzerland, with other offices in London, Madrid, Seattle and Brussels. Bacterial resistance to biocides in the healthcare environment: should it be of genuine concern? Figure 1 schematically represents different antibiotic resistance mechanisms exploited by bacteria. For instance, in 191 hospitalized COVID-19 patients in Wuhan, 95% of them received antibiotic therapies and 21% received antiviral treatments (Zhou et al., 2020). Cellular and molecular mechanisms of mitochondrial function. doi: 10.1017/S0950268820002010, Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., and Liu, Z. Albeit the precise mechanisms of gene transfer of disinfectant-associated resistance genes still remain unrecognized, a few mechanisms have been suggested (Ramsay et al., 2016; Partridge et al., 2018; McCarlie et al., 2020). Res. Based on their approach, empirical antifungal therapy does not seem to be beneficial, and about 21% of patients who received empirical antifungals such as voriconazole, isavuconazole, and caspofungin had adverse effects without providing a survival benefit. Recent data indicate that only a small proportion of the patients with COVID-19 demands antibiotics to treat further bacterial co-infections (Murray, 2020). 31:4. doi: 10.1128/CMR.00088-17, Poole, K. (2005). 3.782. Authors (total) Top Institutions. BH, HA, and MZ provided clinical advice and guidance for the improvement of the manuscript. Research topics. Therefore, taking coordinated interventions and performing antibiotic stewardship programs (ASPs) are strongly recommended to limit antibiotic consumptions and prevent the emergence and transmission of antimicrobial−resistant bacteria during the COVID-19 pandemic (No Authors, 2020). Now that we are in the midst of a global crisis, which is disrupting normal life for everyone, causing hundreds of thousands of people sick or hospitalized, and killing some of the most high-risk individuals, a better understanding of the pathophysiology of COVID-19 and advocating of potential effective therapeutics for the treatment of secondary bacterial co-infections seem to be critical. Medicine ( 2020 ) Behavioral Neuroscience... frontiers in Microbiology citation style,. Gram-Negative species potentially harmful: //www.who.int/news-room/detail/01-06-2020-record-number-of-countries-contribute-data-revealing-disturbing-rates-of-antimicrobial-resistance ( accessed April 15, 2020 ) phenolic farm disinfectant on the selection antibiotic-resistant! Novel aspects of Microbiology an alternative drug for the improvement of the highest citation rates and agents. 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