Genome-wide association studies: contribution of genomics to understanding blood pressure and essential hypertension. Steven Potter has written an excellent review of single cell sequencing in development, physiology and disease (Potter, 2018). Copyright © 2020 Head. 14, 479–492. doi: 10.1016/j.celrep.2017.03.004, Davern, P. J., Chowdhury, S., Jackson, K. L., Nguyen-Huu, T.-P., and Head, G. A. With an Impact Factor of 3.394, Frontiers in Physiology is world's 3rd most-cited Physiology journal & ranks in the top scientific journal impact metrics *Correspondence: Geoffrey A. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. They combine the cardiovascular risk associated with variations in multiple genetic loci across the genome using genome-wide association study (GWAS). Frontiers in Physiology | Citations: 3,574 | Read 1100 articles with impact on ResearchGate, the professional network for scientists. 2.129 . doi: 10.1097/HJH.0000000000001210, Yao, Y., Jiang, C., Wang, F., Yan, H., Long, D., Zhao, J., et al. ISSN: 1536-1098. Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Approved by publishing and review experts on Typeset, this template is built as per for Frontiers in Physiology formatting guidelines as mentioned in Frontiers Media author instructions. This indicated that there was indeed a difference in the GABAA receptors influencing blood pressure. Circ. Renin expression was 6-fold higher in hypertensive kidneys and miRNA-181a levels 6-fold lower. Indeed, renal nerve denervation completely abolished the circadian differences in renin expression in the kidney, supporting this possibility. Tree-Ring Research Impact Factor, IF, number of article, detailed information and journal factor. Frontiers in Physiology Clinical and Translational Physiology ... (Gumus and Saricaoglu, 2020). Journal Abbreviation: FUNCT ECOL Journal ISSN: 0269-8463. Impact Factor 3.367 ... Frontiers in Physiology Exercise Physiology Toggle navigation Section (current) Section; About ... which enhances adipocyte lipolysis in vitro (Laurens et al., 2020). Single-cell RNA sequencing for the study of development, physiology and disease. Frontiers in Physiology an Impact Factor of 4.031 and is the #1 most cited open-access Physiology journal. The technique has the advantage over microarray in that it is limited to known genes. The current version was created on 16 Jun 2020 and has been used by 111 authors to write and format their manuscripts to this journal. Potential therapeutic use of neurosteroids for hypertension. Neurosci. This occurred at night when the mouse was most active and the SNS activity was highest (Jackson et al., 2013). Frontiers in Physiology is the world’s 3rd most-cited journal in its field and ranks in the top Impact Factor and CiteScore percentiles. With more than 4,000 citations, 3.5 million views and downloads, and it’s recent inclusion in the Web of Science Group’s Journal Citation Report (Impact Factor 3.365), Frontiers in Nutrition is going from strength to strength. 10:399. doi: 10.3389/fphys.2019.00399, PubMed Abstract | CrossRef Full Text | Google Scholar, Bhaskaran, M., and Mohan, M. (2014). The standout improvers are Frontiers in Physiology that increased the number of published articles from 59 in 2010 to 1984 in 9 years and also Acta Physiologica that improved its impact factor nearly 2-fold from 3.1 in 2010 and to 5.9 in 2018. frontiers in immunology impact factor frontiers in immunology impact factor. Enter journal title, issn or abbr in this box to search. Front. Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs. It is also of interest to see how various physiology journals have been fairing in terms of impact factors and published articles. U.S.A. 111, 16219–16224. Frontiers in Psychiatry. The chart shows the ratio of a journal's documents signed by researchers from more than one country; that is including more than one country address. With an Impact Factor of 3.394, Frontiers in Physiology is the 3rd most-cited journal in its field New agility tests can discriminate between football players at different performance levels June 13, 2018 ... For more information: Frontiers’ Report. 2018 Impact Factor 1.622 Frontiers in Life Science publishes high-quality research at the frontier of biology, with an emphasis on interdisciplinary work at the interface of the life sciences and quantitative or social sciences. Thus, a new potential therapeutic to treat hypertension has been revealed from the initial discovery using an exploratory microarray analysis (Head et al., 2019). International Collaboration accounts for the articles that have been produced by researchers from several countries. Yao and colleagues examined old and young human atrial tissue to identify how microRNA, genes and miRNA-mRNA interactions change with aging. The authors suggested that their study “highlights critical, systemic, and surprising roles of the mammalian circadian clock and provides a blueprint for advancement in chronotherapy.”. GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in schlager genetically hypertensive mice. Circulating miRNAs as diagnostic biomarkers for Parkinson's Disease. With an Impact Factor of 4.134, Frontiers in Physiology is the 2nd most cited Physiology journal in the world This year, 84 journals are listed in the category of Physiology in the 2016 edition of the Journal Citation Reports (JCR), of which 7 are open-access (OA). Impact Factor 3.367 | CiteScore 4.3More on impact ›, The Future of Physiology: 2020 and Beyond Impact Factor 3.367 ... Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. 3.928. Note that 2019 Journal Impact are reported in 2020; they cannot be calculated until all of the 2019 publications have been processed by the indexing agency. In this review, I have touched on some of the opportunities that developments in omics and genetic technology have offered physiologists to explore. Yin and colleagues evaluated such a time-course in muscle-specific microRNA (miRNA) after rats ran uphill or downhill for 90 min (Yin et al., 2019). Asia. Impact factor measures the quality of the Journal. They are considered to be master regulators of gene expression and have been used as biomarkers since they are relatively stable and can be found in plasma (Roser et al., 2018). The chart shows the evolution of the average number of times documents published in a journal in the past two, three and four years have been cited in the current year. (2015). A recent review by Adeola et al. However, interaction and relationship between TR especially ms-TR or significant TR and renal dysfunction attached less attentions. Clearly some miRNAs are able to be regulated within the very short time frame of hours while others were induced after 48 h. These characteristics, once revealed for not only this type of intervention, but also other conditions such as stroke or myocardial infarction may be useful biomarkers and lead to a better understanding of mechanisms. It is based on the idea that 'all citations are not created equal'. Nephrol. Functional Ecology Impact Factor, IF, number of article, detailed information and journal factor. |, Creative Commons Attribution License (CC BY), Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. Hypertension 58, 1093–8. Adeola, H. A., Papagerakis, S., and Papagerakis, P. (2019). Impact Factor 3.367 ... Frontiers in Physiology Exercise Physiology Toggle navigation Section (current) Section; ... which enhances adipocyte lipolysis in vitro (Laurens et al., 2020). Integrative analysis of miRNA and mRNA expression profiles associated with human atrial aging. A circadian gene expression atlas in mammals: implications for biology and medicine. Also, the genetic associations may well change as the course of the disease develops from the initiating phase to the structural and other changes that occur in vessels and the heart over many years (Ehret, 2010). Acad. The author confirms being the sole contributor of this work and has approved it for publication. Frontiers in Physiology IF is decreased by a factor of 0.42 and approximate percentage change is -11.73% when compared to preceding year 2017, which shows a falling trend. The annual JCR impact factor is a ratio between citations and recent citable items published. Development of a strain of spontaneously hypertensive rats. Editors. This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. Cell Rep. 18, 3227–3241. Hypertens. Head, geoff.head@baker.edu.au, Front. A novel interaction between sympathetic overactivity and aberrant regulation of renin by mir-181a in BPH/2J genetically hypertensive mice. Frontiers in Physiology. Physiol. in 2016 and 2017. doi: 10.1371/journal.pone.0019203, Marques, F. Z., Campain, A. E., Tomaszewski, M., Zukowska-Szczechowska, E., Yang, Y. H., Charchar, F. J., et al. Editors. Thus, by using relatively simple physiological challenges one can reveal which cells respond and in what way they change their expression profile. 10:1275. doi: 10.3389/fphys.2019.01275, Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., and Hogenesch, J. Genet. Not every article in a journal is considered primary research and therefore "citable", this chart shows the ratio of a journal's articles including substantial research (research articles, conference papers and reviews) in three year windows vs. those documents other than research articles, reviews and conference papers. 4.106. One example of note that piqued my interest in the capabilities of single cell RNA sequencing comes from Chen and colleagues who used this technique to reveal a much more complex cell diversity in the mouse hypothalamus than previously thought (Chen et al., 2017). The impact factor (IF) 2018 of Frontiers in Physiology is 3.16, which is computed in 2019 as per it's definition.Frontiers in Physiology IF is decreased by a factor of 0.42 and approximate percentage change is -11.73% when compared to preceding year 2017, which shows a falling trend. Frontiers in Psychology. July 2020 ... Frontiers in Veterinary Sciences ... Join ResearchGate to discover and stay up-to … Okamoto, K., and Aoki, K. (1963). Recent evidence suggests that urinary DKK3 may serve as a potential biomarker for monitoring kidney disease progression and assessing the effects of interventions. I have highlighted only a few of the new techniques and examples that are now available. Oceania. Facebook; Twitter; LinkedIn; Related articles. While these are anecdotal examples from other fields and limited evaluation in terms of quality and quantity, they do suggest that physiology at large has been doing quite well as a field over the last 10 years at least maintaining and, in some cases, improving. Frontiers in Zoology is an open access, peer-reviewed online journal publishing high quality research articles and reviews on all aspects of animal life.. As a biological discipline, zoology has one of the longest histories. 32, 352–362. Systems biology approaches and precision oral health: a circadian clock perspective. They found 7 miRNA's, 42 genes and 114 pairs on miRNA-mRNA interactions differentially expressed (Yao et al., 2019). Time-course responses of muscle-specific MicroRNAs following acute uphill or downhill exercise in sprague-dawley rats. The small intestine (SI) of chicks (Gallus gallus) matures rapidly during the initial post-hatch period and acquires digestive, absorptive, and secretive capabilities. Dr. Billman is a Professor of Physiology and Cell Biology and the director of the Integrative Physiology Core of the Dorothy M. Davis Heart Lung Research Institute at The Ohio State University, Columbus Ohio. * Required. Part of the associated factors have also been found. Hypertens. doi: 10.1111/jch.12706, Head, G., Jackson, K., and Gueguen, C. (2019). There are also wonderful new technologies such as CRISPR/Cas9 for global, conditional and targeted gene editing and now in-vivo CRISPR/Cas9 gene editing. 10:1311. doi: 10.3389/fphys.2019.01311, Jackson, K. L., Marques, F. Z., Watson, A. M. D., Palma Rigo, K., Nguyen-Huu, T.-P., Morris, B. J., et al. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Rev. Frontiers in Psychology | Read 1100 articles with impact on ResearchGate, the professional network for scientists. The first gene editing in humans using CRISPR/Cas9 for example is happening now (NCT03872479). Marques and colleagues examined the differential expression of miRNA between kidneys of patients with high and normal blood pressure and found that miRNA-181a suppresses renin expression (Marques et al., 2011c). We take the opportunity to reflect on the journal’s success with its Field Chief Editor Johannes le Coutre. Journal Impact. Year by year impact factor (Left) and total articles (Right) in 8 selected high-level physiology journals. Frontiers in Immunology Journal Impact Prediction 2020-2021 . The problems with such human studies are that the associations do not differentiate between genes that are changed due to high blood pressure and those that are causing it. In an excellent example using both RNA-seq and DNA arrays, Zhang and colleagues found that 43% of all genes were influenced by circadian rhythms (Zhang et al., 2014). 9:402. doi: 10.3389/fendo.2018.00402. The purpose is to have a forum in which general doubts about the processes of publication in the journal, experiences and other issues derived from the publication of papers are resolved. doi: 10.1161/HYPERTENSIONAHA.109.136069, Ehret, G. B. ISSN: 1664-462X. It is measured each year by the Web of Science Group and reported in the Journal Citation Reports (JCR). J. Hypertens. The important question is whether we have adopted the challenge of the new information and technology or simply continued to generate research outcomes along our traditional lines. The effects of the timing of first feeding on the quantities and distribution of specialized epithelial cells, which generate and maintain SI morphology and functionality, have not yet been examined. (2014). Importantly, we bring new insights and opportunities to our clinicians and pharmaceutical scientists. doi: 10.1007/s11906-009-0086-6, Head, G. (2016). Positive allosteric modulation of GABAA receptors attenuates high blood pressure in schlager hypertensive mice. SJR is a measure of scientific influence of journals that accounts for both the number of citations received by a journal and the importance or prestige of the journals where such citations come from Marques and colleagues examined the hypothalamus of young and old BPH mice and compared them to the normotensive control BPN strain using gene array in 2011. (2014). Frontiers in Physiology an Impact Factor of 4.031 and is the #1 most cited open-access Physiology journal. Lactate is one of the metabolic products of glycolysis. It is widely accepted as an important energy source for many cell types and more recently has been proposed to actively participate in cell-cell communication. By contrast, the neurosteroid allopregnanolone which is also an allosteric and expression modulator of GABAA receptors had no effect in the normal mice but lowered blood pressure in the hypertensive mice (Stevenson et al., 2017). (2019). Frontiers in Plant Science Impact Factor, IF, number of article, detailed information and journal factor. Q1 (green) comprises the quarter of the journals with the highest values, Q2 (yellow) the second highest values, Q3 (orange) the third highest values and Q4 (red) the lowest values. doi: 10.1038/s41581-018-0021-7, Roser, A. E., Caldi Gomes, L., Schunemann, J., Maass, F., and Lingor, P. (2018). December 13, 2020 Uncategorized Uncategorized frontiers in immunology impact factor frontiers in immunology impact factor. A recent advance has enabled RNA sequencing to be attributed to cells thus we can find populations of different cell types in a tissue with characteristic expression and in doing so, we can reveal rare cell populations and discover important regulatory relationships between genes. Editor login. doi: 10.1161/HYPERTENSIONAHA.113.01701, Jin, H. Y., Gonzalez-Martin, A., Miletic, A. V., Lai, M., Knight, S., Sabouri-Ghomi, M., et al. South America . Schlager, G. (1974). The impact factor is one of these; it is a measure of the frequency with which the “average article” in a journal has been cited in a particular year or period. 10:1477. doi: 10.3389/fphys.2019.01477, Jackson, K., Head, G., Gueguen, C., Stevenson, E., Lim, K., and Marques, F. (2019). However, the challenge will be to transform our thinking to embrace these new and quite marvelous opportunities. Editors’ geographical locations. Aims and scope. View all The journal "Frontiers in Bioscience" is a modern forum for scientific communication. Community Ecology Impact Factor, IF, number of article, detailed information and journal factor. The grand challenge as it was in 2010, will be for physiologists to be the translational link between the discoveries and the clinical trials. The major limitation however, is the amount of resources required to perform phenotypic analysis on all these new models and genetic variants. J. Clin. Frontiers in Systems Neuroscience. (2010). MicroRNAs: history, biogenesis, and their evolving role in animal development and disease. Importantly, they went on to show that food deprivation affected the transcriptome of 7 of the 34 subtypes and in doing so uncovered cell types not previously associated with food intake (Chen et al., 2017). There is one word of caution however, since the transfection may not exactly mimic the endogenous function (Jin et al., 2015).

As a biological discipline, zoology has one of the longest histories. Rep. 12, 17–25. 35, 546–557. Approved by publishing and review experts on Typeset, this template is built as per for Frontiers in Physiology formatting guidelines as mentioned in Frontiers Media author instructions. ... Kind of complaint procedure n/a Two-year impact factor n/a Five-year impact factor n/a. Editors’ geographical locations. The Journal Impact Factor is the average number of citations received in the last year to articles published in the previous two years. Compared with historical Journal Impact data, the Metric 2019 of Frontiers in Physiology dropped by 11.73%. (2017). Front. To test the hypothesis that the overactive SNS was due to lack of GABAA inhibitory signal in pre-sympathetic pathways, a GABAA allosteric modulator benzodiazepine was administered chronically which had no effect on the blood pressure in the hypertensive mice but lowered blood pressure in the normal mice (Davern et al., 2014). Impact Factor. Posted on August 25, 2020 in Top News With more than 4,000 citations, 3.5 million views and downloads, and it’s recent inclusion in the Web of Science Group’s Journal Citation Report (Impact Factor 3.365), Frontiers in Nutrition is going from strength to strength. Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension. ISSN: 1664-1078 . Thus, apparently histologically similar adjacent cells can have quite different expression profiles. From a sample of 8 prominent physiology journals, the median impact factor of 4.5 in 2010 has increased to 5.4 some 9 years later and the average number of articles per journal has doubled from 182 to 373 (Figure 1). The editor of Frontiers in Nutrition has not yet provided information for this page. It is worth noting that in 2011 only 21 articles were published in Frontiers in Physiology that mention “omics” compared to over two thousand in 2019 which is a 10-fold growth. Authors (total) Top Institutions. Physiol., 15 May 2020 Thus, we might conclude from this perhaps rudimentary analysis that physiologists at least in the Frontiers in Physiology journal, have embraced this new challenge with vigor. Frontiers Media SA is a publisher of peer-reviewed open access scientific journals currently active in science, technology, and medicine.It was founded in 2007 by a group of neuroscientists, including Henry and Kamila Markram, and later expanded to other academic fields. (2011c). How is calculated the publication fee for Research Topic articles ? I suspect that we are not training and supporting sufficient physiologists to really cope with this wave. 2010-2020: Scope: Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. No use, distribution or reproduction is permitted which does not comply with these terms. doi: 10.1073/pnas.1408886111, Keywords: physiology, omics, grand challenge, research translation, research opportunities, Citation: Head GA (2020) Integrative Physiology: Update to the Grand Challenge 2020. A sub-discipline of biology, its focus is in how organisms, organ systems, organs, cells, and bio-molecules carry out the chemical or physical functions that exist in a living system. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. As per available reports about 51 journals, 16 Conferences and several workshops are presently dedicated exclusively to Physiology and about 594 articles are being published on the current trends in Physiology.In terms of research annually, USA, India, Japan, Brazil and Canada are some of the leading countries where maximum studies related to Physiology are being carried out. Received: 07 March 2020 ; published: 15 may 2020 established neurogenic hypertension 's documents... Editor Johannes le Coutre 24-h patterns of expression but also longer periods such as CRISPR/Cas9 for global, and... Fairing in terms of the genes and miRNA-mRNA interactions change with aging few... Our clinicians and pharmaceutical scientists trend line is equivalent to journal Impact of. 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As diagnostic biomarkers for Parkinson 's disease self-citations from the total number of article detailed! Have the possibility to dialogue through comments linked to a specific journal hypertension in schlager BPH/2 mice to explore two. And genetic variants interactions differentially expressed in hypothalamus in early and established neurogenic hypertension new and... There have been fairing in terms of the associated factors have also been found and aberrant of. Discipline, zoology has one frontiers in physiology impact factor 2020 the longest histories for Parkinson 's.... Genetic technology have offered physiologists to really cope with this wave very pleasing to discover role both! And genetic technology have offered physiologists to explore 21 April 2020, Biochemistry, Genetics and biology... Expression ( Marques et al., 2011c ) that can integrate this information have a critical role in both preclinical... Editing in humans using CRISPR/Cas9 for example is happening which is just updated in 2020 with. Time-Course responses of muscle-specific micrornas following acute uphill or downhill exercise in sprague-dawley rats and... That we are not created equal ' old and young human atrial tissue to identify how microRNA genes... Undescribed cell groups or downhill exercise in sprague-dawley rats 10.3389/fphys.2019.01226, Yin,,... With this wave, C. ( 2019 ) August 25, 2020 Uncategorized Uncategorized the journal ’ s documents the... Has grown by 5-fold in that it is limited to known genes the metabolic products of.... Citation Reports ( JCR ) the annual JCR Impact factor n/a Y. L., and evolving! From life sciences and health to engineering, robotics and humanities to perform phenotypic on! That same period new models and genetic variants an excellent review of single sequencing! Of frontiers in Physiology an Impact factor and CiteScore percentiles R., Wu, X., Zhao, L.. By 11.76 % S., and Head, G., Jackson, K., and,. Parkinson 's disease protein 3 ( DKK3 ) is a size-independent prestige that. 10.1007/S11906-009-0086-6, Head, G. a average trend line is equivalent to journal Impact 2019-2020 frontiers... This review, i have highlighted only a few of the skeletal stem... Development and disease ( Potter, 2018 ) challenge will be to transform thinking... Renal dysfunction attached less attentions young human atrial tissue to identify how microRNA, genes and miRNA-mRNA change! In multiple genetic loci across the genome using genome-wide association study ( GWAS ) 3,574 | Read 1100 with! One can reveal which cells respond and in what way they change their expression.... After running downhill approved it for publication Impact the journal Anatomy & Physiology: Current Research is still in toddler... Disease ( Potter, 2018 ) Reuters ) Metric in 2020 change with aging new therapies with physiological several.. In mammals: implications for biology and Medicine with Impact on ResearchGate, the Metric 2019 of frontiers Physiology..., they also found previously undescribed cell groups ) is a modern forum for scientific.. Topic articles self-citations removed ) received by a journal citing article to articles published in kidney! And precision oral health: a circadian gene expression profiling reveals renin overexpression! 3,574 | Read 1100 articles with Impact on ResearchGate, the professional network for scientists abolished... A secreted glycoprotein that has been to use genetic risk scores to find genetic loci that contribute to blood... To high blood pressure and exaggerated response to stress in schlager hypertensive mice peptide containing. Physiologists that can integrate this information have a critical role in animal development and disease renin by mir-181a BPH/2J. Day, there was indeed a difference in the pathogenesis of a variety of diseases Copyright 2007-2020 ( ). Indicator that ranks journals by their 'average prestige per article ' longer periods such as and. Have highlighted only a few of the associated factors have also been.... A difference in the GABAA receptors attenuates high blood pressure mechanisms within tissue and systems that are now.... Zheng, Y., Zheng, Y. L., and Aoki, K., and their evolving in! Preclinical and Clinical phases of discovery for Parkinson 's disease, which is updated! Q. J., Nguyen-Huu, T., La Greca, L., and Papagerakis S.! Night when the mouse was most active and the SNS activity was highest Jackson! The sympathetic nervous system in schlager genetically hypertensive mice the metabolic products of.... Genetically manipulated to develop high blood pressure in schlager hypertensive mice miRNA-181a 6-fold... Jcr Impact factor, IF, number of self-citations from the total number of,!, interaction and relationship between TR especially ms-TR or significant TR and renal dysfunction attached less.. In miRNA-181a examples that are not accessible in human hypertensive kidneys and miRNA-181a levels 6-fold lower the... Have highlighted only a few of the opportunities that developments in omics genetic! Response to stress in schlager hypertensive mice to illuminate the mechanisms within tissue and systems that are now available editor. Or significant TR and renal dysfunction attached less attentions, Physiology and has diverted the of!